Association of hypercalcemia with biochemical parameters in patients with endocrine disorders

Background. Although today primary hyperparathyroidism and cancers are considered the main factors of hypercalcemia (HC), latter is quite often detected in various endocrinopathies. According to modern data, ionized calcium (Ca2+) an intracellular mediator functioning enzymes hormones. All this determines importance finding out features associations between HC biochemical indicators endocrine disorders, which was purpose study. Materials methods. Retrospectively, according medical histories 537 patients with HC, who were treated at endocrinology clinic V. Danilevsky Institute for Endocrine Pathology Problems 2020–2021, we have analyzed correlations (by content Ca2+) levels phosphorus (P), total protein (TP), aspartate aminotransferase (AST) alanine (ALT) pathologies. Results. A significant difference spectrum degree probability found even within limits one type pathological conditions. In group hypothyroidism, there inverse correlation P (p<0.01) a highly probable AST (p<0.001). At same time, direct association TP (p<0.001), (p<0.001) ALT revealed case Graves’ disease. The following data obtained tumors organs: nontoxic multinodular goiter— (p<0.01); thyroid cancer— (p<0.001); nodular pathology adrenal glands— diabetes mellitus, only (p<0.01). There hyperparathyroidism. Conclusions. Metabolic disorders presence pathologies their own characteristics. nature parameters terms diseases must be taken into account when developing therapeutic strategy hypercalcemia.